Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-Methyl-4-[[(1-methylimidazol-2-yl)methyl]sulfanyl]aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2-(chloromethyl)-1-methyl-1H-imidazole hydrochloride | HCID 2795406 | — |
| 반응물 | 4-Amino-2-methylbenzene-1-thiol | HCID 19867385 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-Methyl-4-[[(1-methylimidazol-2-yl)methyl]sulfanyl]aniline | HCID 43303175 | 90.3% |
반응 단계
To a solution of 4-amino-2-methylthiophenol (500 mg) in methanol (10 ml) was added 1N aqueous solution of sodium hydroxide (12 ml), and a solution of 2-chloromethyl-1-methylimidazole hydrochloride (660 mg) in methanol (10 ml) was added at 0° C. Water was added to the mixture, and the mixture was extracted with ethyl acetate and the organic layer was dried over magnesium sulfate. The solvent was distilled off under reduced pressure and the obtained residue was recrystallized from hexane-ethyl acetate, to give 3-methyl-4-[[(1-methylimidazol-2-yl)methyl]sulfanyl]aniline (757 mg) as crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07262185B2 |
| 출처 데이터셋 | uspto-grants-2007_08 |
| ORD ID | ord-ae67017008b04a2f986cd7277017ef2c |
| 출처 메모 | uspto-grants-2007_08 |