Thionyl Chloride → 5-(Chloromethyl)-1-Ethyl-1H-Imidazole Hydrochloride

HRID 856771노트

반응식

HRID 856771 반응식
[CH2:1]([N:3]1[C:7]([CH2:8]O)=[CH:6][N:5]=[CH:4]1)[CH3:2].S(Cl)([Cl:12])=O>>[ClH:12].[Cl:12][CH2:8][C:7]1[N:3]([CH2:1][CH3:2])[CH:4]=[N:5][CH:6]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 22988641(1-Ethyl-1H-imidazol-5-yl)methanol

생성물 1

HCID 229387405-(Chloromethyl)-1-Ethyl-1H-Imidazole Hydrochloride

반응 조건

온도
90 °C

실험 절차

To 1-ethyl-5-hydroxymethylimidazole (9.5 g), thionyl chloride (50 ml) was added by portions at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure and the obtained residue was dissolved in methanol, and the solvent was distilled off again under reduced pressure. The obtained solid was recrystallized from ethyl acetate, to give 5-chloromethyl-1-ethylimidazole hydrochloride (12.4 g) as colorless crystals.

후처리

  1. customto be at room temperature
  2. distillationThe solvent was distilled off under reduced pressure
  3. dissolutionthe obtained residue was dissolved in methanol
  4. distillationthe solvent was distilled off again under reduced pressure
  5. customThe obtained solid was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-230b7f53409948d0b950c5669e97b5db
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262185B2

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