Thionyl Chloride → HCID 22938531, 화합물

반응식

O[CH2:2][C:3]1[N:7]([CH:8]([CH3:10])[CH3:9])[CH:6]=[N:5][CH:4]=1.S(Cl)([Cl:13])=O>>[ClH:13].[Cl:13][CH2:2][C:3]1[N:7]([CH:8]([CH3:10])[CH3:9])[CH:6]=[N:5][CH:4]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 20568531(1-(propan-2-yl)-1H-imidazol-5-yl)methanol

생성물 1

HCID 22938531HCID 22938531, 화합물

반응 조건

온도: 90 °C

실험 절차

To 5-hydroxymethyl-1-isopropylimidazole (4.5 g), thionyl chloride (20 ml) was added by portions at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure and the obtained residue was dissolved in methanol and the solvent was distilled off again under reduced pressure. The obtained solid was recrystallized from ethyl acetate, to give 5-chloromethyl-1-isopropylimidazole hydrochloride (6.2 g) as colorless crystals.

후처리

customto be at room temperature
distillationThe solvent was distilled off under reduced pressure
dissolutionthe obtained residue was dissolved in methanol
distillationthe solvent was distilled off again under reduced pressure
customThe obtained solid was recrystallized from ethyl acetate

출처 및 근거

ORD 기록: ord-22215d6b82654220bea74dff3256e168
출처 데이터셋: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07262185B2

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