Thionyl Chloride → 5-Chloromethyl-4-methyl-1-propylimidazole hydrochloride
반응식
O[CH2:2][C:3]1[N:7]([CH2:8][CH2:9][CH3:10])[CH:6]=[N:5][C:4]=1[CH3:11].S(Cl)([Cl:14])=O>>[ClH:14].[Cl:14][CH2:2][C:3]1[N:7]([CH2:8][CH2:9][CH3:10])[CH:6]=[N:5][C:4]=1[CH3:11]참가 물질
3
반응 조건
- 온도
- 90 °C
실험 절차
To 5-hydroxymethyl-4-methyl-1-propylimidazole (2.4 g) was added thionyl chloride (10 ml) at 0° C., and the mixture was heated for 30 minutes at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure and the obtained residue was dissolved in methanol. The solvent was distilled off again under reduced pressure, to give 5-chloromethyl-4-methyl-1-propylimidazole hydrochloride (3.13 g) as brown oil.
후처리
- customto be at room temperature
- distillationThe solvent was distilled off under reduced pressure
- dissolutionthe obtained residue was dissolved in methanol
- distillationThe solvent was distilled off again under reduced pressure
출처 및 근거
- ORD 기록
- ord-3112afcb917c407aa31fbe834092ed52
- 출처 데이터셋
- uspto-grants-2007_08
- 특허 번호
- US07262185B2
반응 노트
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