Thionyl Chloride → 3-(Chloromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine hydrochloride

HRID 856787노트

반응식

HRID 856787 반응식
[N:1]1[CH:2]=[C:3]([CH2:10]O)[N:4]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=12.S(Cl)([Cl:14])=O>>[ClH:14].[Cl:14][CH2:10][C:3]1[N:4]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]2=[N:1][CH:2]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 229385385,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-3-ylmethanol

생성물 1

HCID 229385113-(Chloromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine hydrochloride

실험 절차

To 5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-3-yl methanol (1.0 g), thionyl chloride (5 ml) was added at 0° C. After heating to reflux for 40 minutes, the mixture was concentrated under reduced pressure. To the residue was added ethyl acetate, and the precipitated crystals were collected by filtration. The crystals were washed with ethyl acetate, to give 3-(chloromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine hydrochloride (1.03 g) as pale yellow crystals.

후처리

  1. temperatureAfter heating
  2. temperatureto reflux for 40 minutes
  3. concentrationthe mixture was concentrated under reduced pressure
  4. additionTo the residue was added ethyl acetate
  5. filtrationthe precipitated crystals were collected by filtration
  6. washThe crystals were washed with ethyl acetate

출처 및 근거

ORD 기록
ord-5a113966d87b4507ad2682dc12a781c3
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262185B2

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