Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 7-Hydroxy-6-methoxy-1-tetralone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 3,4-Dihydro-6,7-dimethoxy-1(2H)-naphthalenone | HCID 266816 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Hydrogen Bromide | HCID 260 | — |
| 생성물 | 7-Hydroxy-6-methoxy-1-tetralone | HCID 316840 | 81.3% |
반응 단계
A solution of 10 g (0.048 mole) of 6,7-dimethoxy-1-tetralone in 100 ml of HOAc and 100 ml of 48% aqueous HBr was heated at 95° C. for 7 hours. The reaction was cooled to room temperature and poured into water and extracted with EtOAc. The EtOAc layer was dried and evaporated to 12 g of crude product. Purification on 1200 g of silica gel eluting with 10% Et2O in CH2Cl2 gave 7.5 g of product. Mp 147-148° C. (literature mp 148-152° C., Journal of Organic Chemistry, 33, 1968, p. 508).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE039419E1 |
| 출처 데이터셋 | uspto-grants-2006_12 |
| ORD ID | ord-621ac675adbd4667b8f184b2cac9b215 |
| 출처 메모 | uspto-grants-2006_12 |