Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 7-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 7-Hydroxy-6-methoxy-1-tetralone | HCID 316840 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 7-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one | HCID 21862716 | 62.8% |
반응 단계
A mixture of 4.5 g (0.0233 mole) of 7-hydroxy-6-methoxy-1-tetralone, 5.4 g (0.032 mole) of benzyl bromide and 10 g (0.072 mole) of K2CO3 in 150 ml of acetone was heated to reflux overnight. The reaction as cooled, poured into water and extracted with EtOAc. The EtOAc was dried over Na2SO4 and evaporated to give 7 g of crude product. Crystallization with Et2O gave 4.13 g of product as a white solid, mp 110-111° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE039419E1 |
| 출처 데이터셋 | uspto-grants-2006_12 |
| ORD ID | ord-2be790c6a8a041b4bc60d9a2b9a17b3d |
| 출처 메모 | uspto-grants-2006_12 |