3-Bromo-4-fluorobenzaldehyde → 2-Bromo-4-ethenyl-1-fluorobenzene

HRID 857021노트

반응식

HRID 857021 반응식
[Li][CH2:2]CCC.[Br:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][C:14]=1[F:15])[CH:10]=O>C1COCC1>[Br:6][C:7]1[CH:8]=[C:9]([CH:10]=[CH2:2])[CH:12]=[CH:13][C:14]=1[F:15]

참가 물질

4

반응물 2

HCID 1736043-Bromo-4-fluorobenzaldehydeHCID 178418339Butyllithium

생성물 1

HCID 218646502-Bromo-4-ethenyl-1-fluorobenzene

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a suspension of Ph3PCH3Br (57 g) in THF (240 mL) at 0° C. was dropwise added n-BuLi (1.6 N, 100 mL). The resulting mixture was allowed to warm to room temperature and stirred for 1 h. After recooling to 0° C., a solution of 3-bromo-4-fluoro-benzaldehyde (20.3 g) in THF (20 mL) was added. The resulting mixture was allowed to warm to room temperature and stirred for 1 h. The reaction mixture was quenched with water, concentrated, and extracted with methylene chloride. The combined organic layers were dried over magnesium sulfate, concentrated under vacuum. The crude product was purified by flash chromatography eluting with 10% ethyl acetate in hexanes to give the title compound as an oil (18 g).

후처리

  1. customAfter recooling to 0° C.
  2. temperatureto warm to room temperature
  3. stirringstirred for 1 h
  4. customThe reaction mixture was quenched with water
  5. concentrationconcentrated
  6. extractionextracted with methylene chloride
  7. dry with materialThe combined organic layers were dried over magnesium sulfate
  8. concentrationconcentrated under vacuum
  9. customThe crude product was purified by flash chromatography
  10. washeluting with 10% ethyl acetate in hexanes

출처 및 근거

ORD 기록
ord-67f81e632b2240c59db54c3956699f73
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07144881B2

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