Trifluoroacetic acid → (R)-2-Amino-2-(4-fluoro-3-morpholin-4-yl-phenyl)-ethanol

HRID 857024

반응식

HRID 857024 반응식
C(O)(C(F)(F)[F:4])=O.C(OC(=O)[NH:14][C@H:15]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[C:19]=1F)[CH2:16][OH:17])(C)(C)C>C(Cl)Cl>[NH2:14][C@H:15]([C:18]1[CH:23]=[CH:22][C:21]([F:4])=[C:20]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[CH:19]=1)[CH2:16][OH:17]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 69527704(R)-[1-(fluoro-3-morpholin-4-yl-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

생성물 1

HCID 57419699(R)-2-Amino-2-(4-fluoro-3-morpholin-4-yl-phenyl)-ethanol

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of TFA (5 mL) and (R )-[1-(fluoro-3-morpholin-4-yl-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester(1.2 g) in methylene chloride (15 mL) was stirred for 2 h. After concentration, the residue was neutralized with 10 N NaOH and extracted with methylene chloride. The organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo to give the title compound as a solid (720 mg).

후처리

  1. concentrationAfter concentration
  2. extractionextracted with methylene chloride
  3. washThe organic layer was washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-1c91b9a385a647f59644f0ac0b2da3dc
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07144881B2

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