4-Methoxy-1-naphthol → 4,4-dimethoxy-4H-naphthalen-1-one

A solution of 4-methoxy-1-naphthol (2.76 g, 15.8 mmol) and DAIB (6.10 g, 18.9 mmol) on methanol (75 mL) was stirred at 25° C. under a nitrogen atmosphere for 1 h. The resultant dark blue solution was poured into a saturated NaHCO3 (aq) solution (75 mL), then the mixture concentrated to approx. 50 mL in vacuo. The blue oil was extracted with dichloromethane (3×75 mL) and the organic layer washed with water (2×75 mL) and brine (2×75 mL), then dried (MgSO4), filtered and concentrated in vacuo (water bath temperature <40° C.) to yield 4,4-dimethoxy-4H-naphthalen-1-one as a dark-blue semi-solid which was used without further purification; 1H NMR (CDCl3) δ 8.15 (1H, d, J 8.0 Hz, ArH), 7.40–7.85 (3H, m, ArH), 6.90 (1H, d, J 12.2 Hz, H-3), 6.55 (1H, d, J 12.2 Hz, H-2), 3.15 (6H, s, OCH3).

1. concentrationthe mixture concentrated to approx. 50 mL in vacuo
2. extractionThe blue oil was extracted with dichloromethane (3×75 mL)
3. washthe organic layer washed with water (2×75 mL) and brine (2×75 mL)
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated in vacuo (water bath temperature <40° C.)

ORD 기록

ord-86ec5291c9694b74bed5ac9fe40de5b1

출처 데이터셋

uspto-grants-2006_12

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07144893B2