Methanol → Methyl 3-iodo-alpha-methyl-D-phenylalaninate
반응식
[I:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[CH2:5][C@:6]([CH3:11])([C:8]([OH:10])=[O:9])[NH2:7].S(Cl)(Cl)=O.[CH3:19]O>>[I:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[CH2:5][C@:6]([CH3:11])([C:8]([O:10][CH3:19])=[O:9])[NH2:7]참가 물질
4
실험 절차
A solution of 3-iodo-α-methyl-D-phenylalanine (0.9 g) in MeOH (50 ml) was treated with thionyl chloride (3.5 ml) and the mixture was heated to reflux for 3 days. The solvent was removed under reduced pressure and the residue was dissolved in EtOAc and washed with aqueous sodium bicarbonate, brine, dried (MgSO4) and evaporated to dryness to give the title compound (0.73 g) LCMS RT=2.12 min.
후처리
- temperaturethe mixture was heated
- temperatureto reflux for 3 days
- customThe solvent was removed under reduced pressure
- dissolutionthe residue was dissolved in EtOAc
- washwashed with aqueous sodium bicarbonate, brine
- dry with materialdried (MgSO4)
- customevaporated to dryness
출처 및 근거
- ORD 기록
- ord-2645e9c24a324bbf91119a7507b19592
- 출처 데이터셋
- uspto-grants-2006_12
- 특허 번호
- US07144908B2
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