Sodium Cyanate → HCID 69343977, 화합물
반응식
[I:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[CH2:5][C@:6]([CH3:12])([C:8]([O:10][CH3:11])=[O:9])[NH2:7].[O-:16][C:17]#[N:18].[Na+]>C(O)(=O)C.O>[NH2:18][C:17]([NH:7][C@@:6]([CH3:12])([C:8]([O:10][CH3:11])=[O:9])[CH2:5][C:4]1[CH:13]=[CH:14][CH:15]=[C:2]([I:1])[CH:3]=1)=[O:16]참가 물질
5
반응 조건
- 온도
- 20 °C
실험 절차
A mixture of methyl 3-iodo-α-methyl-D-phenylalaninate (0.73 g) in acetic acid (3 ml) and water (1 ml) was treated with sodium cyanate (0.4 g) and stirred for 2 days at 20° C. The solvents were removed under reduced pressure and the residue was diluted with EtOAc. The solution was washed with water, brine, dried (MgSO4) and evaporated to give the title compound (0.82 g) LCMS RT=2.74 min.
후처리
- customThe solvents were removed under reduced pressure
- additionthe residue was diluted with EtOAc
- washThe solution was washed with water, brine
- dry with materialdried (MgSO4)
- customevaporated
출처 및 근거
- ORD 기록
- ord-a453c96a69eb415f831b87da8b044e50
- 출처 데이터셋
- uspto-grants-2006_12
- 특허 번호
- US07144908B2
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