Aminoacetaldehyde dimethyl acetal → N-(2,2-Dimethoxyethyl)-N'-(3-iodophenyl)urea
반응식
[I:1][C:2]1[CH:3]=[C:4]([N:8]=[C:9]=[O:10])[CH:5]=[CH:6][CH:7]=1.[CH3:11][O:12][CH:13]([O:16][CH3:17])[CH2:14][NH2:15]>C(Cl)Cl>[CH3:11][O:12][CH:13]([O:16][CH3:17])[CH2:14][NH:15][C:9]([NH:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([I:1])[CH:3]=1)=[O:10]참가 물질
4
반응 조건
- 온도
- 20 °C
실험 절차
A suspension of 3-iodophenylisocyanate (1.1 g) in DCM (10 ml) was treated with aminoacetaldehyde dimethyl acetal (0.49 ml) and stirred under nitrogen at 20° C. for 24 h. The reaction mixture was quenched by adding MeOH. The solvents were removed under reduced pressure to give the title compound (1.35 g) LCMS RT=2.92 min.
후처리
- customThe reaction mixture was quenched
- additionby adding MeOH
- customThe solvents were removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-05b5adbcf5534c8fbac6b3df4bc730fc
- 출처 데이터셋
- uspto-grants-2006_12
- 특허 번호
- US07144908B2
반응 노트
불러오는 중…