Dimethylformamide → 4-(fluoromethyl)benzoyl Chloride
반응식
[F:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][CH:4]=1.CN(C)C=O.S(Cl)([Cl:19])=O>C1C=CC=CC=1>[F:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([Cl:19])=[O:8])=[CH:5][CH:4]=1참가 물질
5
반응 조건
- 온도
- 40 °C
실험 절차
4-(Fluoromethyl)benzoic acid (6.20 g) was dissolved in 30 ml of benzene, and 0.3 ml of N,N-dimethylformamide was added and then 4.4 ml of thionyl chloride was added dropwise. The mixture was stirred for 1 hour at 40° C. and then heated to reflux for another 1 hour. The solvent was distilled off under reduced pressure to provide 6.70 g of the objective compound as pale yellow oil.
후처리
- temperatureheated
- temperatureto reflux for another 1 hour
- distillationThe solvent was distilled off under reduced pressure
출처 및 근거
- ORD 기록
- ord-b57ceada4d14427da98843fdfed223e8
- 출처 데이터셋
- uspto-grants-2006_12
- 특허 번호
- US07144906B2
반응 노트
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