1-Bromo-2-Chloroethane → 1-(2-Chloroethyl)-4-(methylsulfonyl)piperazine

HRID 85727

반응식

HRID 85727 반응식
[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:4])=[O:3].C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][CH2:19][Cl:20]>C(#N)C>[Cl:20][CH2:19][CH2:18][N:8]1[CH2:9][CH2:10][N:5]([S:2]([CH3:1])(=[O:4])=[O:3])[CH2:6][CH2:7]1

참가 물질

5

반응물 3

HCID 78491-Bromo-2-ChloroethaneHCID 11430Potassium CarbonateHCID 7091611-(Methylsulfonyl)piperazine

생성물 1

HCID 201583501-(2-Chloroethyl)-4-(methylsulfonyl)piperazine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 1-(methylsulfonyl)piperazine (250 mg, 1.522 mmol), potassium carbonate (1262 mg, 9.13 mmol) and 1-bromo-2-chloroethane (1092 mg, 7.61 mmol) in acetonitrile (5 mL) was stirred for 6 hours at room temperature. LCMS indicated the formation of desired product. The reaction mixture was filtered to remove the white precipitate, then quenched with distilled water (10 mL), extracted with ethyl acetate (3×8 mL), the extracts were combined, dried over sodium sulfate, filtered and concentrated under reduced pressure to provide the clean desired product as white solid (100 mg, 29%). LCMS: m/e 227.15 (M+H)+, 1.21 min (method 10).

출처 및 근거

ORD 기록
ord-19ad2a3a85a444e3ba8bdb52476b5267
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846647B2

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