참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Diisobutylaluminumhydride | HCID 21225700 | — |
| 반응물 | Methyl 4-bromo-6-fluoro-1H-indole-2-carboxylate | HCID 21867463 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (4-Bromo-6-fluoro-1h-indol-2-yl)methanol | HCID 21867424 | 96.8% |
반응 단계
To a solution of methyl 4-bromo-6-fluoro-1H-indole-2-carboxylate (3 g, 11 mmol) in THF (50 mL) at −30° C. was added diisobutylaluminum hydride (33 mmol, 1.5M toluene solution). The mixture was stirred for 1 hour at −30° C. and 1N HCl was added. The phases were separated and the aqueous layer was extracted with Et2O. The combined organic layers were dried over Na2SO4 and concentrated to give 2.6 g of the title compound used as such.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07144913B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_12 |
|---|
| ORD ID | ord-62c19ebd538d4c77bd4a41527a3c3744 |
|---|
| 출처 메모 | uspto-grants-2006_12 |
|---|
