Nitromethane → 5-Nitro-2-pentanone

HRID 857441노트

반응식

HRID 857441 반응식
[CH:1]([C:3]([CH3:5])=[O:4])=[CH2:2].[N+:6]([CH3:9])([O-:8])=[O:7].[F-].[K+]>C1COCC1>[N+:6]([CH2:9][CH2:2][CH2:1][C:3](=[O:4])[CH3:5])([O-:8])=[O:7]

참가 물질

5

반응물 3

HCID 6375NitromethaneHCID 6570Methyl vinyl ketoneHCID 522689Potassium Fluoride

생성물 1

HCID 42950035-Nitro-2-pentanone수율 93.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methyl vinyl ketone (4.17 ml, 0.05 moles), nitromethane (24.4 ml, 0.45 moles) and THF (250 ml) were mixed and stirred together under nitrogen. Potassium fluoride on alumina (10 g) was added and the mixture stirred for 2 hours at ambient temperature. The reaction was filtered and the filtrate was evaporated to give crude 5-nitro-2-pentanone as a pale yellow oil (6.11 g, 93%).

후처리

  1. stirringthe mixture stirred for 2 hours at ambient temperature
  2. filtrationThe reaction was filtered
  3. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-4850c597e41e47429cd877545da0ffbf
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07145014B2

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