1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- → N-[5-fluoro-2-(1H-tetraazol-1-yl)benzyl]-L-prolinamide

HRID 857776노트

반응식

HRID 857776 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[N:13][N:12]=[N:11]2)=[C:6]([CH2:8][NH2:9])[CH:7]=1.C([N:22]1[CH2:29][CH2:28][CH2:27][C@H:23]1[C:24](O)=[O:25])(OC(C)(C)C)=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[N:13][N:12]=[N:11]2)=[C:6]([CH:7]=1)[CH2:8][NH:9][C:24](=[O:25])[C@@H:23]1[CH2:27][CH2:28][CH2:29][NH:22]1

참가 물질

3

반응물 2

HCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-HCID 218662261-[5-fluoro-2-(1H-tetraazol-1-yl)phenyl]methanamine

생성물 1

HCID 69655868N-[5-fluoro-2-(1H-tetraazol-1-yl)benzyl]-L-prolinamide

실험 절차

The title compound was prepared essentially according to the procedures described in Example 26, Step B, starting from 1-[5-fluoro-2-(1H-tetraazol-1-yl)phenyl]methanamine and Boc-L-proline.

출처 및 근거

ORD 기록
ord-7e75365b51b24483a806bd8ebbf6d59c
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07144899B2

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