2-(4-(tert-Butoxycarbonyl(methyl)amino) phenyl)acetic acid → HCID 58762829, 화합물

HRID 858057노트

반응식

HRID 858057 반응식
[C:1]([O:5][C:6](=[O:35])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15](=[O:34])[NH:16][C:17]2[C:18](=[O:33])[N:19]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[F:32])[C:20](=[O:24])[NH:21][C:22]=2[NH2:23])=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[C:36](OC(N(C)C1C=CC(CC(O)=O)=CC=1)=O)(C)(C)C>>[C:1]([O:5][C:6](=[O:35])[N:7]([C:8]1[CH:9]=[CH:10][C:11]([CH2:14][C:15](=[O:34])[NH:16][C:17]2[C:18](=[O:33])[N:19]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[F:32])[C:20](=[O:24])[NH:21][C:22]=2[NH2:23])=[CH:12][CH:13]=1)[CH3:36])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 107303972-(4-(tert-Butoxycarbonyl(methyl)amino) phenyl)acetic acidHCID 58762847(4-{[6-Amino-3-(2-fluoro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl]-methyl}-phenyl)-carbamic acid tert-butyl ester

생성물 1

HCID 58762829HCID 58762829, 화합물

실험 절차

Prepared by the same procedure as described for the preparation of (4-{[6-amino-3-(2-fluoro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl]-methyl}-phenyl)-carbamic acid tert-butyl ester (example 1, step 4) except that [4-(tert-butoxycarbonyl-methyl-amino)-phenyl]-acetic acid was used in place of (4-tert-butoxycarbonylamino-phenyl)-acetic acid. Crude (4-{[6-amino-3-(2-fluoro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl]-methyl}-phenyl)-methyl-carbamic acid tert-butyl ester was obtained as a yellow solid which was of sufficient purity for subsequent used without additional purification.

후처리

  1. customPrepared by the same procedure

출처 및 근거

ORD 기록
ord-1e3045f3385e4ac199e931ccc42dec75
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07148229B2

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