Ethylamine → 6-(Ethylamino)pyridine-3-carboxylic acid

반응식

Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12]>>[CH2:11]([NH:13][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1)[CH3:12]

참가 물질

반응물 2

HCID 6341Ethylamine

HCID 792226-Chloronicotinic acid

생성물 1

HCID 117449946-(Ethylamino)pyridine-3-carboxylic acid

실험 절차

This intermediate is prepared from 6-chloronicotinic acid and ethylamine by the same procedure as described for Example 35 step a). 1-Butanol was substituted for ethyl acetate for the extraction. Recrystallization (MeOH—CHCl3) yielded 0.53 g (50%).

후처리

extraction1-Butanol was substituted for ethyl acetate for the extraction
customRecrystallization (MeOH—CHCl3)
customyielded 0.53 g (50%)

출처 및 근거

ORD 기록: ord-6697125ae1594b3486cb3b9065703dba
출처 데이터셋: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07148243B2

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