Isonicotinic Acid → HCID 178473973, 화합물

HRID 858299노트

반응식

HRID 858299 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:13])[CH:11]=2)[CH2:6][C:5]1=[O:14])(=[O:3])[CH3:2].[N:15]1[CH:20]=[CH:19][C:18]([C:21](O)=[O:22])=[CH:17][CH:16]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(CC)CC)C>CN(C=O)C.C(O)(=O)C.O>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:13])[CH:11]=2)[C:6](=[C:21]([OH:22])[C:18]2[CH:19]=[CH:20][N:15]=[CH:16][CH:17]=2)[C:5]1=[O:14])(=[O:3])[CH3:2]

참가 물질

8

반응물 4

HCID 5922Isonicotinic AcidHCID 8471TriethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 116441611-Acetyl-6-chloroindolin-2-one

생성물 1

HCID 178473973HCID 178473973, 화합물

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

6.3 g of 1-acetyl-6-chloro-2-indolinone, 4.06 g pyridine-4-carboxylic acid, 10.6 g TBTU and 21 ml triethylamine are stirred in 60 ml of DMF for 15 hours at ambient temperature. The mixture is combined with water, then adjusted to pH 5 by the addition of 10% acetic acid. The precipitate is suction filtered, washed with water and taken up in ethyl acetate. The solution obtained is dried with sodium sulphate and evaporated almost to dryness. The precipitate obtained is suction filtered and dried at 100° C.

후처리

  1. filtrationfiltered
  2. washwashed with water
  3. customThe solution obtained
  4. dry with materialis dried with sodium sulphate
  5. customevaporated almost to dryness
  6. customThe precipitate obtained
  7. filtrationfiltered
  8. customdried at 100° C.

출처 및 근거

ORD 기록
ord-5a3491756720439c9500648334c12073
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07148249B2

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