Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → HCID 10303760, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | N-(3-Chloropropyl)dibutylamine | HCID 96084 | — |
| 반응물 | 2-Butyl-3-(4-hydroxybenzoyl)-5-hydroxymethyl-1-benzofuran | HCID 69360765 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 생성물 | HCID 10303760 | HCID 10303760 | — |
반응 단계
1.68 g of 2-butyl-3-(4-hydroxybenzoyl)-5-hydroxymethyl-1-benzofuran, 1.18 g of 1-chloro-3-(dibutylamino)propane and 0.960 g of potassium carbonate are dissolved in 70 ml of methyl ethyl ketone. The mixture is brought to reflux for 6 hours, water is added and separation is carried out by settling. Extraction with ethyl acetate and washing with a saturated sodium chloride solution are carried out. Purification is subsequently carried out by chromatography on silica (eluent: 95/5 dichloromethane/methanol), which gives the desired compound in the free base form.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07148240B2 |
| 출처 데이터셋 | uspto-grants-2006_12 |
| ORD ID | ord-d20917c659e24f4b831aac7e156c6639 |
| 출처 메모 | uspto-grants-2006_12 |