Pyridine → N-(4-bromo-2-ethylphenyl)methanesulfonamide
반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[Br:6][C:7]1[CH:13]=[CH:12][C:10]([NH2:11])=[C:9]([CH2:14][CH3:15])[CH:8]=1.N1C=CC=CC=1>ClCCl>[Br:6][C:7]1[CH:13]=[CH:12][C:10]([NH:11][S:2]([CH3:1])(=[O:4])=[O:3])=[C:9]([CH2:14][CH3:15])[CH:8]=1참가 물질
5
실험 절차
Methane sulfonyl chloride (1.93 ml, 0.025M) was added to a solution of 4-bromo-2-ethylaniline (5.0 g, 0.025M) and pyridine (2.02 ml, 0.025M) in dichloromethane (100 ml) at 0° C. The reaction mixture was stirred for 1 hr, after which time it was partitioned between dichloromethane (100 ml) and 1N hydrochloric acid (100 ml). The organics were separated and dried over magnesium sulfate, filtered and concentrated in vacuuo to afford the title compound as a clear oil (4.77 g).
후처리
- customafter which time it was partitioned between dichloromethane (100 ml) and 1N hydrochloric acid (100 ml)
- customThe organics were separated
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuuo
출처 및 근거
- ORD 기록
- ord-203dffaafd3049e69236089ae16ed8d5
- 출처 데이터셋
- uspto-grants-2006_12
- 특허 번호
- US07148226B2
반응 노트
불러오는 중…