Boron tribromide → 2-(2-Fluoro-4-hydroxyphenyl)-2-methylpropanenitrile

HRID 858850노트

반응식

HRID 858850 반응식
[F:1][C:2]1[CH:7]=[C:6]([O:8]C)[CH:5]=[CH:4][C:3]=1[C:10]([CH3:14])([CH3:13])[C:11]#[N:12].B(Br)(Br)Br>C(Cl)Cl>[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:10]([CH3:14])([CH3:13])[C:11]#[N:12]

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 450914982-(2-Fluoro-4-methoxyphenyl)-2-methylpropanenitrile

생성물 1

HCID 601250122-(2-Fluoro-4-hydroxyphenyl)-2-methylpropanenitrile

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-(2-Fluoro-4-methoxy-phenyl)-2-methyl-propionitrile (1.5 g, 7.8 mmol) in CH2Cl2 (75 mL) at −78° C. was added Boron tribromide (1M solution in CH2Cl2) (16 mL, 16 mmol). The solution was allowed to warm to room temperature and stir for 48 hours. The reaction was quenched with 0.5N HCl (50 mL) and poured into water (100 mL). The organic layer was separated and the aqueous was extracted with CH2Cl2 (50 mL). The combined organics were washed with water (100 mL), dried over Na2SO4, filtered and concentrated. The resulting oil was used without further purification.

후처리

  1. customThe reaction was quenched with 0.5N HCl (50 mL)
  2. additionpoured into water (100 mL)
  3. customThe organic layer was separated
  4. extractionthe aqueous was extracted with CH2Cl2 (50 mL)
  5. washThe combined organics were washed with water (100 mL)
  6. dry with materialdried over Na2SO4
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customThe resulting oil was used without further purification

출처 및 근거

ORD 기록
ord-e0b929d53a7b4d5ea427b6c8ffc61b22
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07148226B2

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