Itaconic acid → STK087815

HRID 859202노트

반응식

HRID 859202 반응식
[CH2:1]([O:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:16]([OH:24])(=[O:23])[C:17]([CH2:19][C:20](O)=[O:21])=[CH2:18]>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([N:13]2[C:20](=[O:21])[CH2:19][CH:17]([C:16]([OH:24])=[O:23])[CH2:18]2)=[CH:14][CH:15]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 811Itaconic acidHCID 228604-Benzyloxyaniline

생성물 1

HCID 2968114STK087815수율 96.2%

반응 조건

온도
130 °C

실험 절차

18.8 g (94.4 mmol) of 4-benzyloxyaniline are mixed with 12.28 g (94.4 mmol) itaconic acid. The solid mixture is heated to 130° C. After 20 min the molten material solidifies. After cooling, the resulting solid is triturated with ethyl acetate to yield 28.26 g (96% of theory) of (RS)-1-(4-benzyloxy-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid as a greyish solid. MS: m/e=311 (M)+.

후처리

  1. temperatureAfter cooling
  2. customthe resulting solid is triturated with ethyl acetate

출처 및 근거

ORD 기록
ord-d2c1f1d1ab794804bd1e99d02e1040b9
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07151111B2

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