Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (R)-1-(4-((3-Fluorobenzyl)oxy)phenyl)-5-oxopyrrolidine-3-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | (R)-1-[4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester | HCID 68615673 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | (R)-1-(4-((3-Fluorobenzyl)oxy)phenyl)-5-oxopyrrolidine-3-carboxylic acid | HCID 67411567 | — |
반응 단계
In an analogous manner to that described in Example 2f), the hydrolysis of (R)-1-[4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester with hydrochloric acid (37%) in dioxane yields the (R)-1-[4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid as a white solid. MS: m/e=330 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07151111B2 |
| 출처 데이터셋 | uspto-grants-2006_12 |
| ORD ID | ord-6928739fd60447b583be8d38531acb0a |
| 출처 메모 | uspto-grants-2006_12 |