2-Bromothiazole → (2-Nitro-4-thiazol-2-ylethynyl-phenyl)-carbamic acid tert.-butyl ester

HRID 859292노트

반응식

HRID 859292 반응식
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[CH:15])=[CH:10][C:9]=1[N+:16]([O-:18])=[O:17])([CH3:4])([CH3:3])[CH3:2].Br[C:21]1[S:22][CH:23]=[CH:24][N:25]=1>>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:21]2[S:22][CH:23]=[CH:24][N:25]=2)=[CH:10][C:9]=1[N+:16]([O-:18])=[O:17])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 764302-BromothiazoleHCID 23554338tert-Butyl (4-ethynyl-2-nitrophenyl)carbamate

생성물 1

HCID 69592841(2-Nitro-4-thiazol-2-ylethynyl-phenyl)-carbamic acid tert.-butyl ester수율 62.3%

실험 절차

Prepared from (4-ethynyl-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example F2) (262 mg, 1.00 mmol) and 2-bromothiazole (0.14 mL, 1.50 mmol) according to the general procedure F. Obtained as a yellow solid (215 mg). MS (ISN) 344 [(M−H)−]; mp 137° C.

출처 및 근거

ORD 기록
ord-209d4a73d4f045cba62bc2f62e80be08
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07151098B2

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