Stannous chloride dihydrate → (2-Amino-4-iodo-phenyl)-carbamic acid tert-butyl ester

반응식

[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([I:14])=[CH:10][C:9]=1[N+:15]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([I:14])=[CH:10][C:9]=1[NH2:15])([CH3:4])([CH3:2])[CH3:3]

참가 물질

반응물 2

HCID 61436Stannous chloride dihydrate

HCID 23554339Tert-butyl (4-iodo-2-nitrophenyl)carbamate

생성물 1

HCID 69592774(2-Amino-4-iodo-phenyl)-carbamic acid tert-butyl ester수율 99.8%

실험 절차

Prepared from (4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example A1) (2.18 g, 6.0 mmol) by reduction with SnCl2.2H2O (6.77 g, 30 mmol) according to the general procedure G (method b). Obtained as a brown-yellow solid (2.0 g).

출처 및 근거

ORD 기록: ord-fa93c4c82c9b4c4fa5e904b487bc4bb2
출처 데이터셋: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07151098B2

반응 노트

불러오는 중…