Thionyl Chloride → HCID 69592852, 화합물

HRID 859361노트

반응식

HRID 859361 반응식
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([F:12])=[C:7]([CH:11]=1)[C:8](Cl)=[O:9])#[N:2].O=S(Cl)Cl.[K+].[C:18]([O:24][CH2:25][CH3:26])(=[O:23])[CH2:19]C([O-])=O.[Mg+2].[Cl-].[Cl-]>C1(C)C=CC=CC=1.CC#N.CCN(CC)CC.CN(C=O)C>[CH2:25]([O:24][C:18](=[O:23])[CH2:19][C:8]([C:7]1[CH:11]=[C:3]([C:1]#[N:2])[CH:4]=[CH:5][C:6]=1[F:12])=[O:9])[CH3:26]

참가 물질

9

반응물 4

HCID 24386Thionyl ChlorideHCID 3446434Potassium ethyl malonateHCID 5360315Magnesium ChlorideHCID 21942520HCID 21942520, 화합물

생성물 1

HCID 69592852HCID 69592852, 화합물

시약·촉매·용매 4

HCID 1140Toluene용매HCID 6228Dimethylformamide용매HCID 6342Acetonitrile용매HCID 8471Triethylamine용매

실험 절차

Prepared from 5-cyano-2-fluoro-benzoyl chloride [prepared from the corresponding acid [CAS-No. 146328-87-2] by treatment with SOCl2, cat. DMF in toluene at 80° C.] by reaction with ethyl malonate potassium salt with Et3N and MgCl2 in CH3CN according to general procedure H (method a). Obtained as a light yellow solid (3.85 g).

출처 및 근거

ORD 기록
ord-0cc6a63e52fc4c89b9ad4c671d1e8519
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07151098B2

반응 노트

불러오는 중…