Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(2-Amino-4-phenylethynyl-phenyl)-carbamic acid tert-butyl ester → {2-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-phenylethynyl-phenyl}-carbamic acid tert.-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (2-Amino-4-phenylethynyl-phenyl)-carbamic acid tert-butyl ester | HCID 11404065 | — |
| 반응물 | 3-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile | HCID 11736337 | — |
| 생성물 | {2-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-phenylethynyl-phenyl}-carbamic acid tert.-butyl ester | HCID 11167526 | 77.5% |
반응 단계
Prepared from (2-amino-4-phenylethynyl-phenyl)-carbamic acid tert.-butyl ester (Example G2) (214 mg, 0.7 mmol) and 3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile (Example J4) (250 mg, 1.1 mmol) according to the general procedure K. Obtained as a light yellow solid (260 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07151098B2 |
| 출처 데이터셋 | uspto-grants-2006_12 |
| ORD ID | ord-ad9505f265294b639eaf418afe9a6529 |
| 출처 메모 | uspto-grants-2006_12 |