2,2-Dimethyl-6-thiophen-2-yl-[1,3]dioxin-4-one → HCID 86588008, 화합물

HRID 859400노트

반응식

HRID 859400 반응식
[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14](=[O:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:10][C:9]=1[NH2:22])([CH3:4])([CH3:3])[CH3:2].CC1(C)[O:30][C:29](=O)[CH:28]=[C:27]([C:32]2[S:33][CH:34]=[CH:35][CH:36]=2)[O:26]1>>[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14](=[O:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:10][C:9]=1[NH:22][C:29](=[O:30])[CH2:28][C:27](=[O:26])[C:32]1[S:33][CH:34]=[CH:35][CH:36]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 222247082,2-Dimethyl-6-thiophen-2-yl-[1,3]dioxin-4-oneHCID 69592848Carbamic acid,(2-amino-4-benzoylphenyl)-,1,1-dimethylethyl ester

생성물 1

HCID 86588008HCID 86588008, 화합물수율 25.8%

실험 절차

Prepared from (2-amino-4-benzoyl-phenyl)-carbamic acid tert.-butyl ester (Example G24) (259 mg, 0.5 mmol) and 2,2-dimethyl-6-thiophen-2-yl-[1,3]dioxin-4-one (Example J1) (135 mg, 0.55 mmol) according to the general procedure K. Obtained as a light yellow solid (60 mg).

출처 및 근거

ORD 기록
ord-8fea0574091a4774a34ae32e64bee2c1
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07151098B2

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