Trifluoroacetic acid → 4-(7-Cyclopropyl-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-pyridine-2-carbonitrile

HRID 859572노트

반응식

HRID 859572 반응식
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:16][CH2:15]2)=[CH:10][C:9]=1[NH:17][C:18](=[O:30])[CH2:19][C:20]([C:22]1[CH:27]=[CH:26][N:25]=[C:24]([C:28]#[N:29])[CH:23]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:14]1([C:11]2[CH:12]=[CH:13][C:8]3[N:7]=[C:20]([C:22]4[CH:27]=[CH:26][N:25]=[C:24]([C:28]#[N:29])[CH:23]=4)[CH2:19][C:18](=[O:30])[NH:17][C:9]=3[CH:10]=2)[CH2:16][CH2:15]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86588064{2-[3-(2-Cyano-pyridin-4-yl)-3-oxo-propionylamino]-4-cyclopropyl-phenyl}-carbamic acid tert.-butyl ester

생성물 1

HCID 222247014-(7-Cyclopropyl-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-pyridine-2-carbonitrile

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Prepared from {2-[3-(2-cyano-pyridin-4-yl)-3-oxo-propionylamino]-4-cyclopropyl-phenyl}-carbamic acid tert.-butyl ester (Example K79) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light brown solid (88 mg).

출처 및 근거

ORD 기록
ord-072071ec390a4dd5b894c444b493393d
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07151098B2

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