Acetylacetone → (5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol

HRID 859615

반응식

HRID 859615 반응식
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH2:7][OH:8])[N:3]=1.[CH3:9][C:10](=O)[CH2:11][C:12](=O)[CH3:13]>C(O)(=O)C>[CH3:9][C:10]1[CH:11]=[C:12]([CH3:13])[N:6]2[N:5]=[C:4]([CH2:7][OH:8])[N:3]=[C:2]2[N:1]=1

참가 물질

4

반응물 2

HCID 31261AcetylacetoneHCID 178508559HCID 178508559, 화합물

생성물 1

HCID 44141733(5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol수율 95%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a slurry of (5-amino-1H-[1,2,4]triazol-3-yl)-methanol (9.5 g, 50 mmol) from step 6 above in acetic acid (200 mL) was added 2,4-pentanedione (5.13 mL, 50 mmol). The mixture was heated to reflux for 4 hours, and then cooled to room temperature. The product was isolated by removing the solvent by rotary evaporation (8.5 g, 95% yield). MS (ESI): 179 (M+H).

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 4 hours
  3. customThe product was isolated
  4. customby removing the solvent
  5. customby rotary evaporation (8.5 g, 95% yield)

출처 및 근거

ORD 기록
ord-ce51570e726a43719dd7dd1d2b6e6c65
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07151105B2

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