참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethylamine hydrochloride | HCID 11198 | — |
| 반응물 | 4-Pyrimidinamine, 2,6-dichloro- | HCID 82387 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | 6-Chloro-N2-ethylpyrimidine-2,4-diamine | HCID 23435529 | — |
반응 단계
A mixture of 2,6-dichloro-4-aminopyrimidine 18-1 (Avocado; 4.8 g, 29.3 mmol), ethylamine hydrochloride (7.0 g, 85.8 mmol), Et3N (20 mL, 144 mmol) and n-butanol (150 mL) was heated to 90° C. for 6 hours. After cooling, the solvent was removed in vacuo and the residue partitioned between saturated Na2CO3 solution and EtOAc. The EtOAc layer was washed with brine, dried (MgSO4) and concentrated to give an orange solid. Purification by column chromatography (EtOAc/hexane 1:1) gave the title compound 18-2 as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07153862B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_12 |
|---|
| ORD ID | ord-f375066a496849a29a18fbc735d95bb3 |
|---|
| 출처 메모 | uspto-grants-2006_12 |
|---|
