Dimethylformamide → 3-(4-Fluoro-phenyl)-2-methyl-5-(2-methyl-pyridin-4-ylethynyl)-3H-imidazole-4-carbaldehyde

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([C:13]#[C:14][C:15]3[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[CH:16]=3)[N:10]=[C:9]2[CH3:22])=[CH:4][CH:3]=1.CN(C)[CH:25]=[O:26]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH:25]=[O:26])=[C:11]([C:13]#[C:14][C:15]3[CH:20]=[CH:19][N:18]=[C:17]([CH3:21])[CH:16]=3)[N:10]=[C:9]2[CH3:22])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 6228Dimethylformamide

HCID 100856604-[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine

생성물 1

HCID 100645323-(4-Fluoro-phenyl)-2-methyl-5-(2-methyl-pyridin-4-ylethynyl)-3H-imidazole-4-carbaldehyde

실험 절차

3-(4-Fluoro-phenyl)-2-methyl-5-(2-methyl-pyridin-4-ylethynyl)-3H-imidazole-4-carbaldehyde (89) [MS: m/e=320.4 (M+)] was prepared in analogy to the method as above from 4-[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine (1) and N,N-dimethyl-formamide.

출처 및 근거

ORD 기록: ord-4d35909819ba496d990c87561fbb50e4
출처 데이터셋: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07153874B2

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