2-Chloroveratraldehyde → N-(2-chloro-3,4-dimethoxybenzylideneamino)-N'-hydroxy-N''-phenylguanidine

HRID 860181노트

반응식

HRID 860181 반응식
[Cl:1][C:2]1[C:9]([O:10][CH3:11])=[C:8]([O:12][CH3:13])[CH:7]=[CH:6][C:3]=1[CH:4]=O.S([C:18]1[CH:24]=[CH:23][C:21](C)=[CH:20][CH:19]=1)(O)(=O)=O.[OH:25][NH:26][C:27]([NH:29][NH:30]C1C=CC=CC=1)=[NH:28]>CO>[Cl:1][C:2]1[C:9]([O:10][CH3:11])=[C:8]([O:12][CH3:13])[CH:7]=[CH:6][C:3]=1[CH:4]=[N:30][NH:29][C:27]([NH:26][OH:25])=[N:28][C:18]1[CH:24]=[CH:23][CH:21]=[CH:20][CH:19]=1

참가 물질

4

반응물 2

HCID 794452-ChloroveratraldehydeHCID 178427661HCID 178427661, 화합물

생성물 1

HCID 86590910N-(2-chloro-3,4-dimethoxybenzylideneamino)-N'-hydroxy-N''-phenylguanidine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

0.22 g (1.1 mmol) 2-chloro-3,4 dimethoxybenzaldehyde and 0.34 g (1 mmol) N-hydroxy-N′-phenylaminoguanidine tosylate was mixed in 7 ml methanol. The reaction mixture was refluxed for 80 min after which it was cooled down, to room temperature. The solvent was evaporated and 10 ml acetonitile was added and the solution was stirred for 1 h. The precipitate formed was filtered, washed with ether and subseqently dried. The yield of title compound 2 was 0.40 g (77%) as a crystalline solid M.p. 167–169° C.

후처리

  1. temperatureThe reaction mixture was refluxed for 80 min after which it
  2. customThe solvent was evaporated
  3. addition10 ml acetonitile was added
  4. customThe precipitate formed
  5. filtrationwas filtered
  6. washwashed with ether
  7. customsubseqently dried

출처 및 근거

ORD 기록
ord-bf477626a78644a384a8cc8ca00661d9
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07153881B2

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