Water → HCID 57444530, 화합물

HRID 860416노트

반응식

HRID 860416 반응식
[C:1]([C:4]([C:18](=[O:27])[C:19]1[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=1)(C(=O)C)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])(=[O:3])[CH3:2].C(OCC)(=O)C.O>FC(F)(F)C(O)=O>[C:25]([C:22]1[CH:21]=[CH:20][C:19]([C:18]([CH:4]([C:1](=[O:3])[CH3:2])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[O:27])=[CH:24][CH:23]=1)#[N:26]

참가 물질

5

반응물 3

HCID 962WaterHCID 8857Ethyl AcetateHCID 57444529Ethyl 7-acetyl-7-(4-cyanobenzoyl)-8-oxononanoate

생성물 1

HCID 57444530HCID 57444530, 화합물수율 72.5%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

반응 조건

온도
20 °C

실험 절차

Ethyl 7-acetyl-7-(4-cyanobenzoyl)-8-oxononanoate (3.5 g) was dissolved in trifluoroacetic acid (12.6 ml) and the mixture was stirred at 20° C. for 15 minutes. The mixture was partitoned between ethyl acetate and water. The organic layer was separated, washed with water, aqueous sodium bicarbonate and brine, dried over MgSO4 (magnesium sulfate), and evaporated to give ethyl 7-(4-cyanobenzoyl)-8-oxononanoate (2.25 g) as an oil.

후처리

  1. customThe organic layer was separated
  2. washwashed with water, aqueous sodium bicarbonate and brine
  3. dry with materialdried over MgSO4 (magnesium sulfate)
  4. customevaporated

출처 및 근거

ORD 기록
ord-e00be75486dc4cbcb2c46c3115462fa4
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07153854B2

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