Benzyl chloroformate → Methyl 4-({[(benzyloxy)carbonyl]amino}sulfonyl)benzoate

HRID 860417노트

반응식

HRID 860417 반응식
[NH2:1][S:2]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].C(=O)([O-])[O-].[K+].[K+].[CH:21]1[CH:26]=[CH:25][C:24]([CH2:27][O:28][C:29](Cl)=[O:30])=[CH:23][CH:22]=1>C(COC)OC>[CH2:27]([O:28][C:29]([NH:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:13][CH:14]=1)(=[O:3])=[O:4])=[O:30])[C:24]1[CH:25]=[CH:26][CH:21]=[CH:22][CH:23]=1

참가 물질

5

반응물 3

HCID 10387Benzyl chloroformateHCID 11430Potassium CarbonateHCID 89847Methyl 4-sulphamoylbenzoate

생성물 1

HCID 57444531Methyl 4-({[(benzyloxy)carbonyl]amino}sulfonyl)benzoate수율 40.8%

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매2회

실험 절차

A mixture of methyl 4-(aminosulfonyl)benzoate (5.10 g) and potassium carbonate (6.55 g) in dimethoxyethane (50 mL) was refluxed for 5 minutes. After cooling the mixture, a solution of benzyl chloridocarbonate (5.25 g) in dimethoxyethane (30 mL), and the resulting mixture was refluxed for 1 hour. The reaction was quenched by adding 1N hydrochloric acid (100 mL). The mixture was extracted with ethyl acetate (200 mL), and the organic layer was washed with brine, dried over magnesium sulfate, and evaporated to give a pale yellow oil, which was solidified upon standing. The solid was triturated in diisopropyl ether (30 mL) to give methyl 4-({[(benzyloxy)carbonyl]amino}sulfonyl)benzoate as a white powder (3.38 g).

후처리

  1. temperaturewas refluxed for 5 minutes
  2. temperatureAfter cooling the mixture
  3. customThe reaction was quenched
  4. additionby adding 1N hydrochloric acid (100 mL)
  5. extractionThe mixture was extracted with ethyl acetate (200 mL)
  6. washthe organic layer was washed with brine
  7. dry with materialdried over magnesium sulfate
  8. customevaporated
  9. customto give a pale yellow oil, which
  10. customThe solid was triturated in diisopropyl ether (30 mL)

출처 및 근거

ORD 기록
ord-736265cd995d4267a52dc15d729d1bb6
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07153854B2

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