Ethanol → Ethyl 7-oxo-7-phenylheptanoate

HRID 860422

반응식

HRID 860422 반응식
[C:1]([CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O-][CH2:17][CH3:18].[Na+].C([OH:22])C>>[O:8]=[C:1]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:9][CH2:14][CH2:13][CH2:12][CH2:11][C:10]([O:15][CH2:17][CH3:18])=[O:22]

참가 물질

4

반응물 3

HCID 702EthanolHCID 2756272-BenzoylcyclohexanoneHCID 2723922Sodium ethoxide

생성물 1

HCID 11107694Ethyl 7-oxo-7-phenylheptanoate

실험 절차

A mixture of 2-benzoylcyclohexanone (1.00 g), sodium ethoxide (404 mg) in ethanol (5 mL) was stirred for 3.5 hours at room temperature. The reaction was quenched by adding 1N hydrochloric acid (1 mL). The solvent was evaporated off, and the residue was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over magnesium sulfate, and evaporated to give ethyl 7-oxo-7-phenylheptanoate as a brown oil (1.33 g).

후처리

  1. customThe reaction was quenched
  2. additionby adding 1N hydrochloric acid (1 mL)
  3. customThe solvent was evaporated off
  4. customthe residue was partitioned between ethyl acetate and water
  5. washThe organic layer was washed with brine
  6. dry with materialdried over magnesium sulfate
  7. customevaporated

출처 및 근거

ORD 기록
ord-c27831a485234b90b51bf50b96a7b44c
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07153854B2

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