Ethanol → HCID 69589287, 화합물
반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:16]=[CH:15][C:11]([C:12]([NH2:14])=[S:13])=[CH:10][N:9]=1.[CH3:17][O:18][C:19](=[O:27])[CH:20]([CH3:26])[C:21](=O)[CH:22](Br)[CH3:23].[CH2:28](O)C>>[CH2:17]([O:18][C:19](=[O:27])[CH:20]([C:21]1[N:14]=[C:12]([C:11]2[CH:10]=[N:9][C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])=[CH:16][CH:15]=2)[S:13][C:22]=1[CH3:23])[CH3:26])[CH3:28]참가 물질
4
실험 절차
A mixture of 6-(2-Fluoro-phenyl)-thionicotinamide (3.0 g, 12 mmol) and 4-bromo-3-oxo-2-methyl-pentanoic acid methyl ester (3.2 g, 14.4 mmol) in ethanol (100 mL) is heated to reflux for 24 h, and concentrated. The residue is purified by column chromatography on silica gel yielding 2.6 g of the product.
후처리
- temperatureis heated
- temperatureto reflux for 24 h
- concentrationconcentrated
- customThe residue is purified by column chromatography on silica gel yielding 2.6 g of the product