Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thioglycolic Acid → [[[2-Amino-5-(4-chlorobenzoyl)phenyl](3-chlorophenyl)methyl]thio]-acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thioglycolic Acid | HCID 1133 | — |
| 반응물 | 2-Amino-alpha-(3-chlorophenyl)-5-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-benzenemethanol | HCID 69019808 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | [[[2-Amino-5-(4-chlorobenzoyl)phenyl](3-chlorophenyl)methyl]thio]-acetic acid | HCID 69020567 | 95.1% |
반응 단계
A mixture of intermediate (9) (0.088 mol) and mercapto-acetic acid (0.0836 mol) in HCl 6N (500 ml) was stirred and refluxed for 1 hour, then cooled and poured out into ice water. The precipitate was filtered off, washed with water and taken up in DCM. The organic solution was dried (MgSO4), filtered and the solvent was evaporated till dryness. The product was used without further purification, yielding 35.5 g (90.5%) of [[[2-amino-5-(4-chlorobenzoyl)phenyl](3-chlorophenyl)methyl]thio]-acetic acid (intermediate 19).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07153958B2 |
| 출처 데이터셋 | uspto-grants-2006_12 |
| ORD ID | ord-11ef54fa87a2412992b6b2735c607d93 |
| 출처 메모 | uspto-grants-2006_12 |