참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Venlafaxine | HCID 5656 | — |
| 반응물 | 1-Dodecanethiol | HCID 8195 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 생성물 | Desvenlafaxine | HCID 125017 | — |
반응 단계
Dodecanethiol (69 g), venlafaxine (55 g), and an ethanolic solution of sodium ethanolate (21%, 82 g) are charged to a pressure vessel. The temperature is raised to 150° C. and the reaction mixture is stirred for 2 days. Then the temperature is lowered and the solution is filtered. The pH of the filtrate is adjusted to 9.5 with aqueous hydrogen chloride. The crystals are collected by suction filtration. The cake is washed with ethanol and dried in vacuo.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07154001B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_12 |
|---|
| ORD ID | ord-1f210c72ef1d4d6dbed5314b68ac8d0c |
|---|
| 출처 메모 | uspto-grants-2006_12 |
|---|
