Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 6-Bromo-3-[[2-(trimethylsilyl)ethoxy]methyl]-3H-imidazo[4,5-b]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 6-Bromo-4H-imidazo[4,5-b]pyridine | HCID 911578 | — |
| 반응물 | 2-Chloromethyl 2-(trimethylsilyl)ethyl ether | HCID 2724271 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ammonium Chloride | HCID 25517 | — |
| 생성물 | 6-Bromo-3-[[2-(trimethylsilyl)ethoxy]methyl]-3H-imidazo[4,5-b]pyridine | HCID 19358288 | — |
반응 단계
To a solution of 6-bromo-3H-imidazo[4,5-b]pyridine (1.0 eq.) (see J. Am. Chem. Soc. 1957, 6421.) in DMF (0.2M) was added NaH (1.4 eq.). The mixture was stirred for 30 min then SEM-Cl (2.0 eq.) was added. The final mixture was stirred for 2 h, poured in saturated aqueous NH4Cl and extracted with EtOAc (2×). The combined organic extracts were washed with water (3×), brine, dried over Na2SO4, filtered and concentrated. Flash chromatography (Hex:EtOAc; 7:3) afforded the title compound as a foam.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07153968B2 |
| 출처 데이터셋 | uspto-grants-2006_12 |
| ORD ID | ord-1aba1eec898d468b848cfef32b7a44af |
| 출처 메모 | uspto-grants-2006_12 |