Acetyl chloride → 2-Allyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenol
반응식
[C:1](Cl)(=O)[CH3:2].[CH2:5]([C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1[OH:18])[C:11](=[N:13][OH:14])[NH2:12])[CH:6]=[CH2:7]>N1C=CC=CC=1>[CH2:5]([C:8]1[CH:9]=[C:10]([C:11]2[N:12]=[C:1]([CH3:2])[O:14][N:13]=2)[CH:15]=[CH:16][C:17]=1[OH:18])[CH:6]=[CH2:7]참가 물질
4
실험 절차
Acetyl chloride (2.28 ml) was added dropwise to a solution of 3-allyl-4-hydroxybenzamidoxime (5.4 g) in pyridine (48 ml). The solution was heated at reflux for 16 hours, cooled to ambient temperature and evaporated. The residue was dissolved in ethyl acetate and the solution was washed with saturated aqueous sodium carbonate solution, dried (MgSO4) and evaporated, to give 2-allyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenol as a low-melting solid (3.8 g), m/z 217 (M+H).
후처리
- temperatureThe solution was heated
- temperatureat reflux for 16 hours
- customevaporated
- dissolutionThe residue was dissolved in ethyl acetate
- washthe solution was washed with saturated aqueous sodium carbonate solution
- dry with materialdried (MgSO4)
- customevaporated
출처 및 근거
- ORD 기록
- ord-7390b4b2ffc34ea8b1fd4bfabde9e5ff
- 출처 데이터셋
- uspto-grants-1998_02
- 특허 번호
- US05714496
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