Sodium Acetate → 6-(2-methoxycarbonyl-1-pyrrolyl)-7-nitro-2,3(1H,4H)-quinoxalinedione

HRID 861464노트

반응식

HRID 861464 반응식
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[C:6](=[O:16])[NH:5]2.[CH3:17][O:18][C:19]([C:21]1(OC)[CH2:25][CH2:24][CH:23](OC)O1)=[O:20].C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH3:17][O:18][C:19]([C:21]1[N:1]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][C:11]=2[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[C:6](=[O:16])[NH:5]3)[CH:23]=[CH:24][CH:25]=1)=[O:20]

참가 물질

5

반응물 3

HCID 517045Sodium AcetateHCID 39809926-Amino-7-nitroquinoxaline-2,3-diolHCID 13152840Methyl tetrahydro-2,5-dimethoxyfuroate

생성물 1

HCID 220970806-(2-methoxycarbonyl-1-pyrrolyl)-7-nitro-2,3(1H,4H)-quinoxalinedione

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

7 g (27.1 mmol) of 6-amino-7-nitro-2,3(1H,4H)-quinoxalinedione, 5.1 g (27.1mmol) of 2-methoxycarbonyl-2,5-dimethoxytetrahydrofuran and 4.5 g (54.2 mmol) of sodium acetate in 500 ml of glacial acetic acid were refluxed for one hour. The reaction mixture was concentrated and then the crude product was purified by column chromatography on silica gel (mobile phase: toluene/acetone/glacial acetic acid=10/10/1).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customthe crude product was purified by column chromatography on silica gel (mobile phase: toluene/acetone/glacial acetic acid=10/10/1)

출처 및 근거

ORD 기록
ord-3d1833f5cb154c518be7932d2e3ad6b4
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05714489

반응 노트

불러오는 중…