1,1'-Thiocarbonyldiimidazole → 1-[(2-(2,6-Difluorophenyl)ethyl)thiocarbamoyl]imidazole

HRID 861612노트

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HRID 861612 반응식
[C:1]([N:8]1[CH:12]=[CH:11]N=C1)([N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1)=[S:2].[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:15]=1CCN>C(#N)C>[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:15]=1[CH2:11][CH2:12][NH:8][C:1]([N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1)=[S:2]

참가 물질

4

반응물 2

HCID 802641,1'-ThiocarbonyldiimidazoleHCID 37461112-(2,6-Difluorophenyl)ethan-1-amine

생성물 1

HCID 152056241-[(2-(2,6-Difluorophenyl)ethyl)thiocarbamoyl]imidazole수율 124.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 1,1'-thiocarbonyldiimidazole (9.5 g, 48 mmol) and 2-(2,6-difluorophenyl)ethylamine (7.54 g, 48 mmol) in acetonitrile (100 mL) was stirred at room temperature for 20 h. The solution was concentrated under reduced pressure and the resulting precipitate was collected by filtration and triturated with hexane to provide 16 g of crude titled product as a brown solid:

후처리

  1. concentrationThe solution was concentrated under reduced pressure
  2. filtrationthe resulting precipitate was collected by filtration
  3. customtriturated with hexane

출처 및 근거

ORD 기록
ord-02667c8ff85d4eceac3f39333387eb3e
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05714503

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