Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-N,N-diethyl-1,1,2-trifluoroethan-1-amine → 3beta-Hydroxy-7beta-ethenyl-5-androsten-17-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-N,N-diethyl-1,1,2-trifluoroethan-1-amine | HCID 136184 | — |
| 반응물 | 3beta-Benzyloxy-5-androsten-17-one | HCID 53764908 | — |
| 생성물 | 3beta-Hydroxy-7beta-ethenyl-5-androsten-17-one | HCID 67648341 | — |
반응 단계
Reaction of 3β,16α-dihydroxyandrost-5-en-17-one 3β-acetate 1 with a fluorinating agent such as diethyl (2-chloro-1,1,2-trifluoroethyl)amine affords 16α-fluoro-3β-hydroxyandrost-5-en-17-one 3-acetate 3. Hydrolysis of the ester with aqueous acid yields 16α-fluoro-3β-hydroxyandrost-5-en-17-one, 2a. ##STR47##
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05714481 |
| 출처 데이터셋 | uspto-grants-1998_02 |
| ORD ID | ord-990edd6dac1548d3a5c5d4640812abd9 |
| 출처 메모 | uspto-grants-1998_02 |