Phenylhydrazine → 6-Phenyl-8-(3-nitrophenyl) pyrido[2,3-d]pyridazin-5-one

HRID 861952노트

반응식

HRID 861952 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:19]=[CH:20][CH:21]=1)[C:7]([C:9]1[C:14]([C:15]([O:17]C)=O)=[CH:13][CH:12]=[CH:11][N:10]=1)=O)([O-:3])=[O:2].[C:22]1([NH:28][NH2:29])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(O)C>[C:22]1([N:28]2[C:15](=[O:17])[C:14]3[CH:13]=[CH:12][CH:11]=[N:10][C:9]=3[C:7]([C:6]3[CH:19]=[CH:20][CH:21]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=3)=[N:29]2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

4

반응물 2

HCID 7516PhenylhydrazineHCID 197007162-(3-Nitrobenzoyl)-3-methoxycarbonylpyridine

생성물 1

HCID 538506476-Phenyl-8-(3-nitrophenyl) pyrido[2,3-d]pyridazin-5-one수율 21%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 2-(3-nitrobenzoyl)-3-methoxycarbonylpyridine (0.26 g, 0.97 mmoles) dissolved in ethanol (50 ml), was added phenylhydrazine (0.25 ml, 2.4 mmoles). The mixture was refluxed for 168 hours. The solvent was removed and the solid was precipitated from ethanol and dried, yielding 0.07 g of 6-phenyl-8-(3-nitrophenyl) pyrido[2,3-d]pyridazin-5-one (21%), mp 167° C.

후처리

  1. temperatureThe mixture was refluxed for 168 hours
  2. customThe solvent was removed
  3. customthe solid was precipitated from ethanol
  4. customdried

출처 및 근거

ORD 기록
ord-8f0f0911f84c4fb081874095f8476667
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05716954

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