Chlorine → Ethyl 5-[(diethoxyphosphinyl)hydroxymethyl]imidazo[1,2-a]pyridine-2-carboxylate, monohydrochloride

HRID 861998노트

반응식

HRID 861998 반응식
[CH2:1]([O:3][P:4]([CH:9]([OH:24])[C:10]1[N:15]2[CH:16]=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:18]=[C:14]2[CH:13]=[CH:12][CH:11]=1)([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].P(CC1C2N(C=C(C(O)=O)N=2)C=CC=1)(O)(O)=O.O1CCOCC1.[Cl:48]Cl>>[ClH:48].[CH2:1]([O:3][P:4]([CH:9]([OH:24])[C:10]1[N:15]2[CH:16]=[C:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:18]=[C:14]2[CH:13]=[CH:12][CH:11]=1)([O:6][CH2:7][CH3:8])=[O:5])[CH3:2]

참가 물질

5

반응물 4

HCID 24526ChlorineHCID 312751,4-DioxaneHCID 15233873Ethyl 5-[(diethoxyphosphinyl)hydroxymethyl]imidazo[1,2-a]pyridine-2-carboxylateHCID 19701381HCID 19701381, 화합물

생성물 1

HCID 131720464Ethyl 5-[(diethoxyphosphinyl)hydroxymethyl]imidazo[1,2-a]pyridine-2-carboxylate, monohydrochloride수율 99%

실험 절차

The product from Example 55 (1.2 g, 3.37 mmol) was dissolved in CH2 Cl2 (15 mL) and treated with 6N HCl in dioxane (0.56 mL, 3.37 mmol). The resulting salt was precipitated with Et2O, filtered, washed with Et2O, and dried in vacuo to give 1.3 g (99%) of the title product.

후처리

  1. customThe resulting salt was precipitated with Et2O
  2. filtrationfiltered
  3. washwashed with Et2O
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-f854f89bc13243bfb3e84961edbbc3f3
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05716964

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