Potassium Cyanide → Ethyl 5-(cyanomethyl)imidazo[1,2-a]pyridine-2-carboxylate

HRID 862001노트

반응식

HRID 862001 반응식
Cl[CH2:2][C:3]1[N:8]2[CH:9]=[C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1.[C-:17]#[N:18].[K+]>CN(C=O)C>[C:17]([CH2:2][C:3]1[N:8]2[CH:9]=[C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1)#[N:18]

참가 물질

4

반응물 2

HCID 9032Potassium CyanideHCID 19701283Ethyl 5-(chloromethyl)imidazo[1,2-a]pyridine-2-carboxylate

생성물 1

HCID 19701198Ethyl 5-(cyanomethyl)imidazo[1,2-a]pyridine-2-carboxylate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
0 °C

실험 절차

Title material is made by dissolving the title product of Example 5 in DMF and after cooling to 0° C., reacting with KI and KCN. The reaction is stirred for 6 h at 0° C. After warming to room temperature, title compound is obtained by diluting with CHCl3, washing with water, and removing all solvent in vacuo.

후처리

  1. temperatureAfter warming to room temperature

출처 및 근거

ORD 기록
ord-a9f32087fa6042738af023682b205495
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05716964

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